Lysomal Storage Disorder

The Dwarf Pony

Mucopolysaccharidosis Type II

Mucopolysaccharidosis type II (MPS II, Hunter disease, defect of the enzyme iduronate-sulfatase) is an X-linked storage disorder; therefore almost solely male patients are affected. The clinical signs and symptoms are comparable with those of mucopolysaccharidosis type I, corneal clouding, however is absent. Characteristic striking features in Hunter disease are pronounced joint contractures. The phenotypic spectrum ranges from a severe (neurological) form with a profound visceral and skeletal manifestation and intellectual disability to a very mild form with only a few somatic features normal intelligence.

Mucopolysaccharidosis Type II | SphinCS - Clinical Science for LSD

Synonym: Hunter syndrome
Etiology: Deficiency of iduronate-2-sulfatase
Gene: IDS Gene
Vererbungsmodus: X-chromosomal
Phenotypes:

  • Neuropathic form
  • Non-neuropathic form

Leading symptoms:
Neuropathic form

  • Inguinal/ umbilical hernia
  • Skeletal abnormalities: dysostosis multiplex, joint contractures
  • Facial dysmorphia
  • Hepatosplenomegaly
  • Psychomotor development delay
  • Hearing impairment

Non-neuropathischic Form

  • Inguinal/ umbilical hernia
  • Skeletal abnormalities: dysostosis multiplex, joint contractures
  • Facial dysmorphia
  • Hepatosplenomegaly
  • Heart valve insufficiency/ stenosis
  • Carpal tunnel syndrome
  • Hearing impairment

Diagnostics:

  • Measurement of the activity of iduronat-2-sulfatase (preferred in serum or dried blood spot
  • Molecular genetic analysis of IDS Gene

Therapy:
Idursulfase (Elaprase®)

Current Studies

The "U.S. National Library of Medicine" provides a complete list of all international studies at www.clinicaltrials.gov. The comparable EU website is less comprehensive: www.clinicaltrialsregister.eu.

Self-help groups

Gesellschaft für Mukopolysaccharidosen e.V.
https://mps-ev.de/

At the moment we are not aware of any self-help groups.

Literature

At present we have no literature available.