SphinCS - Clinical Science for LSD

Get to know us

At SphinCS we have organised our activities distributed over two entities: SphinCS and SphinCSLyso. 
We are a specialized team with extensive knowledge and experience in the field of LSDs, led by Dr. Eugen Mengel and Petra Kleinhans. The patron is Prof. Michael Beck.

The international research in the field of LSDs was co-designed and advanced by Prof. Dr. Beck and Dr. Eugen Mengel (photo). In the last 25 years, therapies have been approved for 9 (of > 50) LSDs. Prof. Dr. Beck and Dr. Mengel were significantly involved in 8 diseases.

SphinCS - Clinical Science for LSD | SphinCS - Clinical Science for LSD | Hochheim

Cooperative Research

As an independent institute for clinical research in the field of LSD, our focus is on promising new drugs for LSDs at a high level in all phases and aspects of clinical research.

We want to give German speaking patients the opportunity to participate in future studies with new drugs.

We pursue the concept that patients play an active role in clinical research. Cooperation with self-help groups is an essential aspect of our approach. 

Team of SphinCS - Clinical Research for LSD

What we work on

  • New drugs for previously untreated lysosomal storage diseases.
  • Optimization of diagnostics to avoid diagnostic errors in the future.
  • Influence of the diseases on the psyche of a patient as well as the family burden.
  • Effects of epilepsy in lysosomal storage diseases.
  • Increase in the success of treatment of epilepsy in lysosomal storage disorders.
  • Improvements in approved drugs.
SphinCS - Clinical Science for LSD | What we work on

We research for you

CEO

Dr. Eugen Mengel

Principle investigator, founder and CEO of the SphinCS GmbH & SphinCS Lyso non-profit UG. Dr. Mengel has dedicated himself to research in the field of LSDs, and has already significantly contributed to the advancement of this field of study. 

Dr. Eugen Mengel | SphinCS - Clinical Science for LSD

Consultant

Prof. Dr. Michael Beck

Prof. Dr. Beck has a broad scientific background in: medicine, paediatrics, biochemistry and human genetics. He has been influential internationally in progressing the field of study of LSDs. At SphinCS he works as a consultant. 

Prof. Dr. Michael Beck | SphinCS - Clinical Science for LSD

Coordinator

Petra Kleinhans

Petra Kleinhans is a registered specialist paediatric nurse and has been working in the field of lysosomal storage disorders for over 16 years. During this time, she has developed her expertise in phase I-IV clinical trials. In addition to study coordination and study management, project development is one of her main activities.
At the Hochheim site, the co-founder of SphinCS organises studies of rare to ultra-rare diseases.

Petra Kleinhans | SphinCS - Clinical Science for LSD

Senior Clinical Research Physician | Pediatrician

Dr. med. Yasmina Amraoui

Mrs. Dr. Amraoui has 15 years of expertise in the diagnosis, care and treatment of patients with lysosomal storage disorders, which she acquired during her work as a specialist in paediatrics and adolescent medicine at the University Medical Center Mainz. Ms. Dr. Amraoui participated as an investigator in more than 30 clinical trials and was instrumental in the research of various lysosomal storage disorders and the approval of various drugs. In October 2019 Dr. Amraoui has joined the SphinCS team as a highly experienced investigator. In addition to leading and conduction of clinical trials, her activities include project development. 

Dr. med. Yasmina Amraoui  | SphinCS - Clinical Science for LSD

Medical Doctor

Dr. Grecia Mendoza Rios

After completing her medicine study at the Mexican University Michoacan of Saint Nicholas of Hidalgo, Ms. Rios worked as an emergency doctor. She joined the SphinCS team in 2020. 

Dr. Grecia Mendoza Rios | SphinCS - Clinical Science for LSD

Study Coordination

Loreen Gramsch

Loreen Gramsch is a certified pediatric nurse and completed a 1/2 year training as a study assistant in the year 2011. In 2009 she worked as a study coordinator in phase I-IV in clinical trials. In the last 4 years, she has acquired a high level of professional competence in the field of lysosomal memory diseases.
In April 2020, Ms. Gramsch has joined the SphinCS team with her expertise as a study coordinator. In addition to the coordination and conduct of clinical trials, their activities include project development.

Loreen Gramsch | SphinCS - Clinical Science for LSD

Clinical Research Physician

Dr. med. Verena Schädlich

Dr. Schädlich started her education at the Paediatric Nursing School Johannes-Gutenberg Mainz. She is a qualified medical doctor involved in clinical research since 2016.

Dr. med. Verena Schädlich | SphinCS - Clinical Science for LSD